Synthesis of Δ12,14-15-deoxy-PG-J1 methyl ester and epi-Δ12-15-deoxy-PG-J1

Autor:	Yingfa Li, Paul Evans, Mazhar Iqbal
Rok vydání:	2004
Předmět:	Chemistry Stereochemistry Organic Chemistry Drug Discovery Biochemistry Conjugate
Zdroj:	Tetrahedron. 60:2531-2538
ISSN:	0040-4020
DOI:	10.1016/j.tet.2004.01.048
Popis:	The synthesis of racemic Δ12,14-15-deoxy-PG-J1 is readily achieved in six steps employing as the key transformation a one-pot conjugate addition–Peterson olefination sequence using exo-2-trimethylsilyl-3a,4,7,7a-tetrahydro-4,7-methanoinden-1-one. Additionally a Noyori-type three-component coupling approach is employed for the synthesis of enantioenriched epi-Δ12-15-deoxy-PG-J1 from 4(S)-tert-butyldimethylsilyloxycyclopent-2-enone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2368e940ccaffc2a53111c28f131980c https://doi.org/10.1016/j.tet.2004.01.048 Zobrazit plný text záznamu Full Text from ScienceDirect