High-intensity interval training slows down tumor progression in mice bearing Lewis lung carcinoma
| Autor: | Gabriel Cardial Tobias, Daniele de Paula Faria, Camila de Godoi Carneiro, Camila Maria de Melo, Ney R. de Almeida, Patricia Chakur Brum, Alexandre T. Garcez, Christiano R. R. Alves, Roger Chammas, Raphael Ferreira de Paiva Barreto, Willian das Neves |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty animal structures urogenital system Angiogenesis business.industry Lewis lung carcinoma Skeletal muscle Cancer medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Endocrinology Tumor progression 030220 oncology & carcinogenesis Internal medicine medicine Tumor necrosis factor alpha Lung cancer business High-intensity interval training |
| Zdroj: | JCSM Rapid Communications. 1:1-10 |
| ISSN: | 2617-1619 |
| DOI: | 10.1002/j.2617-1619.2018.tb00008.x |
| Popis: | Background: The effects of high-intensity interval training (HIIT) in cancer progression are still unknown. Here, we aimed to evaluate whether a short-term HIIT protocol would counteract tumor progression in an experimental model of lung cancer. Methods: Mice were injected subcutaneously with Lewis Lung Carcinoma (LLC) cells and then randomly assigned into two groups: sedentary mice (LLC group) or mice submitted to HIIT (LLC + HIIT group). Results: LLC + HIIT group had lower tumor mass than LLC group (-52% after 18 days), even though no differences were found for tumor morphology or glycolytic capacity. HIIT increased Cd274 (PD-L1) mRNA levels by ~6 fold and tended to increase Tnfa and Il6 mRNA levels in LLC tumors. Moreover, HIIT increased Vegfa mRNA levels by 2.5 fold and tended to increase Pparg1a mRNA levels, suggesting that HIIT stimulates local inflammation and angiogenesis in LLC tumors. Additionally, HIIT improved running capacity and skeletal muscle contractile function in LLC tumor-bearing mice. Conclusions: HIIT attenuates tumor growth and increases the mRNA levels of genes involved in inflammation and angiogenesis in LLC tumor-bearing mice. Additionally, HIIT improves running capacity and skeletal muscle function in LLC tumor-bearing mice. Therefore, this study provides pre-clinical evidence that HIIT may be a beneficial co-therapy for lung cancer. |
| Databáze: | OpenAIRE |
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