Adiponectin and Inflammation in Health and Disease: An Update
| Autor: | Raymond Zerbe, Maria Francis, Charbel F Matar, Hanine Haidar, Estelle Filfili, Alice Gerges Geagea, Abdo Jurjus, Samir G. Mallat |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment 030209 endocrinology & metabolism Inflammation Disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine Interleukin 6 General Environmental Science biology Adiponectin business.industry General Engineering medicine.disease Obesity AdipoRon 030104 developmental biology Cytokine chemistry Immunology biology.protein General Earth and Planetary Sciences medicine.symptom business |
| Zdroj: | Open Medicine Journal. 5:20-32 |
| ISSN: | 1874-2203 |
| DOI: | 10.2174/1874220301805010020 |
| Popis: | Adiponectin, a protein secreted by adipocytes, gained a special medical attention in the past two decades mostly due to its relation to obesity, a major health problem worldwide. Moreover, adiponectin has shown to have a preventive effect on insulin resistance, diabetes and cardiovascular diseases. Lately, obesity has been classified as a chronic inflammatory state, whereby dysregulated adipocytes and high infiltration of macrophages shift toward the production of pro-inflammatory cytokines like TNF-α and IL-6 among others. This status contributes to a decrease in adiponectin levels, thus leading to the emergence of obesity related complications. This review will focus on the hormone adiponectin and its mechanisms of action in relation to insulin resistance, diabetes, cardiovascular effect and atherosclerosis. It will also cover the various therapeutic approaches aiming to increase the levels of this important cytokine, and to highlight the promising role of AdipoRon, an adiponectin receptor agonist, and of diet. |
| Databáze: | OpenAIRE |
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