Prosthetic arachnoid granulations using 3D printing technology
| Autor: | Francis Kralickk, Tzu Li Liu, Sulmaz Zahedi, R. Justin Garling, Carolyn A. Harris, Mark Ming-Cheng Cheng |
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| Rok vydání: | 2017 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Materials science business.industry 3D printing Pressure dependent Arachnoid granulation medicine.disease nervous system diseases Hydrocephalus law.invention Cerebrospinal fluid medicine.anatomical_structure law medicine Subarachnoid space business Stereolithography Superior sagittal sinus Biomedical engineering |
| Zdroj: | 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS). |
| DOI: | 10.1109/memsys.2017.7863463 |
| Popis: | Hydrocephalus, a disorder of excess cerebrospinal fluid, affects roughly 1 in 500 live births per year. Communicating, or extra-ventricular hydrocephalus, is a subset of the disorder that is, in part, a result of arachnoid granulation dysfunction. Arachnoid granulations are innate one-way valves that allow for pressure dependent absorption of cerebrospinal fluid from the subarachnoid space into the venous blood flow of the superior sagittal sinus. This study investigates a bead-based microfluidic diode as a self-regulated shunt valve for mimicking the physiological functions of arachnoid granulations. The proposed device has been fabricated using assembly of several parts manufactured by 3D printing (stereolithography). The additive manufacturing allows layer-by-layer deposition of soft polymer with high precision. The performance of bead-based arachnoid granulations has been preliminarily tested, including penetration into biological tissues and benchtop flow tests. |
| Databáze: | OpenAIRE |
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