Diastereoselective synthesis of polypropionates: Cationic couplings of 4-acetoxy-1,3-dioxanes with crotyl-metal reagents

Autor:	Christopher J. Sinz, Scott D. Rychnovsky
Rok vydání:	1998
Předmět:	chemistry.chemical_classification Stereochemistry Chemistry Organic Chemistry Cationic polymerization Biochemistry Metal Crotyl chemistry.chemical_compound visual_art Reagent Drug Discovery visual_art.visual_art_medium Propionate Lewis acids and bases Methyl group
Zdroj:	Tetrahedron Letters. 39:6811-6814
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(98)01464-6
Popis:	Lewis acids promote the coupling of 4-acetoxy-1,3-dioxanes 1 with crotyl-metal species to generate propionate motifs such as 2. The reactions show a marked dependence on Lewis acid, the crotyl metal species, and the presence and stereochemical disposition of a C5 methyl group. A 1,3-syn methyl relationship is favored in these additions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::234ed3e7afeae8e7b74f473476c09e36 https://doi.org/10.1016/s0040-4039(98)01464-6 Zobrazit plný text záznamu Full Text from ScienceDirect