Autor:	André Mazabraud, Vicki Haedens, Philippe Silar, Zakia Derhy, Michèle Rossignol
Rok vydání:	2000
Předmět:	Genetics Aging media_common.quotation_subject Longevity Mutagenesis (molecular biology technique) Biology biology.organism_classification Gene dosage Yeast Podospora anserina Stop codon Geriatrics and Gerontology Gerontology Developmental biology Gene media_common
Zdroj:	Biogerontology. 1:47-54
ISSN:	1389-5729
DOI:	10.1023/a:1010029723081
Popis:	eEF1A is encoded by a unique gene in the filamentous fungus Podospora anserina. We show here that (1) this gene is essential for vegetative growth, (2) readthrough at UGA stop codon level is positively correlated with eEF1A level, (3) eEF1A level is regulated in P. anserina. (4) Increasing eEF1A gene dosage does not modify P. anserina life cycle parameters, especially longevity is not changed. These data confirm and extend those previously obtained in yeast and Drosophila.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::234c62b62e5c09a45ebd757ab6d7f330 https://doi.org/10.1023/a:1010029723081 Zobrazit plný text záznamu