Interaction between pathogenic fungi in culture. Considerations on the mechanism of cell division in the dimorphism of pathogenic fungi

Autor: Otis F. Jillson, Walter J. Nickerson
Rok vydání: 1943
Předmět:
Zdroj: Mycopathologia. 4:279-283
ISSN: 1573-0832
0301-486X
DOI: 10.1007/bf01237153
Popis: A mutual antagonism (in vitro) has been shown betweenTrichophyton rubrum andCandida albicans by means of two membered pure cultures and by means of cultures filtrates from each organism grown singly. The growth ofT. rubrum was inhibited by metabolic products ofC. albicans. The pigment ofT. rubrum has been shown to be a pH indicator in vivo. Metabolic products ofT. rubrum completely inhibit the development of mycelia byC. albicans, but have little effect on growth in the yeast phase. Chemical fractionation experiments indicated that there are two diffusible metabolic products ofT. rubrum affecting mycelia development: 1) soluble in water and in acetone, heat stable, and adsorbed by activated charcoal, 2) soluble in water, insoluble in acetone, heat labile, and not adsorbed by activated charcoal. The general phenomenon of yeast to mycelia conversions has been considered in detail. A notation system has been developed in this connection; yeast (Y) to mycelia (M) transformations may be expressed as Y→M; interconversions of the type exhibited byBlastomyces may be written Y:⇉M. The relationships between these processes and the analogous bacteria (B) to filament (F) conversions, B→ F, has been pointed out. Evidence that Y.→.M, Y⇄M, and B→F may result from the inhibition of a common unit enzymatic mechanism has been presented. Converging evidence from such diverse fields as the physicochemical study of the kinetics of bacterial growth (Hinshelwood), genetics of irradiated bacteria (Witkin; Eisenstark andClark), cytochemical mechanism of penicillin action (Pratt andDufrenoy), and dimorphism of pathogenic fungi (this paper;Nickerson andEdwards) are all interpreted as pointing in this direction.
Databáze: OpenAIRE
Externí odkaz: