Serum Preptin and Amylin Values in Psoriasis Vulgaris and Behçet's Patients
| Autor: | Demet Cicek, Fatma Baskaya Dogan, Haydar Uçak, Ilker Erden, Betül Demir, Nurhan Halisdemir, Suleyman Aydin, Selma Bakar Dertlioglu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Amylin Behcet's disease 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Internal medicine Psoriasis medicine Immunology and Allergy 030203 arthritis & rheumatology Triglyceride business.industry Insulin Biochemistry (medical) Public Health Environmental and Occupational Health Hematology medicine.disease stomatognathic diseases Medical Laboratory Technology Endocrinology chemistry Metabolic syndrome business Hormone |
| Zdroj: | Journal of Clinical Laboratory Analysis. 30:165-168 |
| ISSN: | 0887-8013 |
| DOI: | 10.1002/jcla.21831 |
| Popis: | Background Insulin resistance is found in both psoriasis and Behcet's disease. No study has yet explored whether preptin and amylin, two hormones associated with insulin resistance, are involved in the insulin resistance observed in patients with psoriasis and Behcet's disease. Objectives We aimed to explore how the amounts of preptin and amylin change in psoriasis and Behcet's disease and whether they are involved in the etiopathology of these two diseases, by comparing hormone levels in patients and healthy controls. Methods The study registered 30 patients with psoriasis, 30 patients with Behcet's disease, and 30 healthy volunteers (as a control group). Fasting blood sugar, triglyceride, LDL, VLDL, HDL, total cholesterol, HbA1c, C-peptide, insulin, and serum preptin and amylin levels were measured in all subjects. Results Serum preptin and amylin levels were significantly lower in the patients with psoriasis and Behcet's disease than in the control group (P < 0.001, P = 0.004, and P = 0.008, respectively). A comparison of the serum preptin and amylin levels between the patients with psoriasis and Behcet's disease did not reveal a statistically significant difference. Serum insulin level and The homeostasis model assessment of insulin resistance (HOMA-IR) index were significantly lower in the psoriasis patient group relative to the control group (P = 0.02 and P = 0.03, respectively), while the values for the Behcet's disease group did not differ significantly from those for the control group Conclusions Serum levels of preptin and amylin were significantly lower in patients with psoriasis and Behcet's disease, indicating that these hormones may be a factor for development of metabolic syndrome in these two diseases. |
| Databáze: | OpenAIRE |
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