Investigation of biodistribution of gold nanoparticles in healthy animals

Autor:	M. L. Bugrova, Ludmila B. Snopova, Elena V. Zagainova, Vadim Elagin, Marina V. Shirmanova, Marina A. Sirotkina, V. A. Nadtochenko, N. N. Denisov
Rok vydání:	2010
Předmět:	Biodistribution Materials science medicine.anatomical_structure Transmission electron microscopy Colloidal gold General Engineering medicine Nanoparticle General Materials Science Nanotechnology Spleen Pharmacology Condensed Matter Physics
Zdroj:	Nanotechnologies in Russia. 5:409-416
ISSN:	1995-0799 1995-0780
DOI:	10.1134/s1995078010050162
Popis:	The goal of this work is to investigate the peculiarities of biodistribution and the effects of gold nanoparticles in different organs and tissues of animals after intravenous administration. Nanoparticles are shown to produce neither acute nor long-term pathomorphologic alterations in the organs of healthy mice. Using transmission electron microscopy, a significant number of nanoparticles were detected in blood and urine 4 h after administration. Gold nanoparticles are shown to accumulate primarily in the spleen and kidneys, with a peak accumulation being reached on day 7 after injection. Single nanoparticles are detected in the brain, heart, and liver.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::234527d83021094f3328b7e79f98ee1a https://doi.org/10.1134/s1995078010050162 Zobrazit plný text záznamu Full text from SpringerLink