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The brain metabolite kynurenic acid (KYNA, Moroni et al., 1988 J.Neurochem. 51, 177), is a broad spectrum antagonist of excitatory amino acid receptors, can antagonize the strychnine-insensitive glycine site associated with the N-methyl-D-aspartate receptor (Carter 1992 Drug Future, 595; Stone, 1993, Pharmacol. Rev. 45, 309) and has neuroprotective and anticonvulsant properties (Foster et al., 1984 Neurosci. Lett. 48, 273; Andine et al., ,1988 Neurosci. Lett., 90, 208). KYNA has been speculatively linked to the pathogenesis of epilepsy and several other brain disorders (Schwarcz et al., 1992 Ann. N.Y. Acad. Sci., 648, 140; Stone 1993 Pharmacol Rev. 45, 309). |
