ChemInform Abstract: Homolytic Substitution Reactions of Electron-Rich Pentatomic Heteroaromatics by Electrophilic Carbon-Centered Radicals. Synthesis of α-Heteroarylacetic Acids

Autor:	Enrico Baciocchi, G. Sleiter, E. Muraglia
Rok vydání:	2010
Předmět:	Indole test Substitution reaction chemistry.chemical_compound chemistry Yield (chemistry) Electrophile General Medicine Electron Carbon centered radicals Photochemistry Medicinal chemistry Pyrrole Homolysis
Zdroj:	ChemInform. 24
ISSN:	0931-7597
Popis:	Efficient and selective homolytic substitutions (yield between 55 and 90%) of pyrrole, indole, and some pyrrole derivatives have been carried out using ambiphilic and electrophilic carbon centered radicals, generated in DMSO by Fe 2+ /H 2 O 2 and α-cyano-, α-carbonyl-, and α,α'-dicarbonylalkyl iodides. The reaction is highly successfull also with pyrroles substituted by electron-withdrawing groups, which has allowed an efficient synthesis of Tolmetin
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::23317c176119100aa36844953ce9d00c https://doi.org/10.1002/chin.199318072 Zobrazit plný text záznamu Plný text