The scavenging of oxidants by sulphasalazine and its metabolites

Autor:	John Butler, Mohammad Wasil, Barry Halliwell, Brigid M Hoey, Okezie I. Aruoma
Rok vydání:	1987
Předmět:	Pharmacology Aminosalicylic acid Hypochlorous acid medicine.drug_class Chemistry Radical Inflammation Biochemistry Anti-inflammatory chemistry.chemical_compound Deoxyribose Radiolysis medicine Hydroxyl radical medicine.symptom
Zdroj:	Biochemical Pharmacology. 36:3739-3742
ISSN:	0006-2952
DOI:	10.1016/0006-2952(87)90028-1
Popis:	Sulphasalazine (Salazopyrin) and its metabolites sulphapyridine and 5-aminosalicylate are powerful scavengers of the hydroxyl radical, determined by pulse radiolysis and confirmed by assays based on deoxyribose degradation by hydroxyl radicals. 5-Aminosalicylate can also protect alpha 1-antiprotease against attack by the myeloperoxidase-derived oxidant hypochlorous acid. The ability to scavenge oxidants produced at sites of inflammation may contribute to the anti-inflammatory action of sulphasalazine and its metabolites.
Databáze:	OpenAIRE
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