In vitro studies of 223Ra- and 225Ac-labelled α-zirconium phosphate as potential carrier for alpha targeted therapy

Autor:	Michal Sakmár, Lukáš Ondrák, Kateřina Fialová, Martin Vlk, Ján Kozempel, Frank Bruchertseifer, Alfred Morgenstern
Rok vydání:	2023
Předmět:	Nuclear Energy and Engineering Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health Radiology Nuclear Medicine and imaging Pollution Spectroscopy Analytical Chemistry
Zdroj:	Journal of Radioanalytical and Nuclear Chemistry. 332:1527-1532
ISSN:	1588-2780 0236-5731
DOI:	10.1007/s10967-022-08742-y
Popis:	In this study suitability of α-ZrP nanoparticles as a 223Ra and 225Ac carriers for TAT was investigated. The yields of radiolabelling were higher than 98% in both cases. Subsequently, in vitro stability studies were carried out in various biological matrices during 48 h period. Measurements of released radioactivity showed the highest stability in saline. Released activity of 223Ra, 225Ac and their daughter radionuclides was around 0.5%. On the other hand, the lowest stability was shown in plasma and serum. Released activity for 223Ra, 225Ac and their progeny atoms was from 15 to 32%.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2320a3391eaa3870fb26848c067a0c15 https://doi.org/10.1007/s10967-022-08742-y Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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