ARE SUBTHALAMICUS NUCLEUS, INTERNAL GLOBUS PALLIDUS AND THALAMUS INVOLVED IN THINKING?
| Autor: | Alexandra Minksová, Zuzana Hummelová, Martin Bareš, Eduard Minks, Jan Chládek, Pavel Jurák, Josef Halamek |
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| Rok vydání: | 2015 |
| Předmět: |
Parkinson's disease
Deep brain stimulation Essential tremor medicine.medical_treatment Thalamus Mismatch negativity Cognition medicine.disease 03 medical and health sciences Psychiatry and Mental health Subthalamic nucleus Epilepsy 0302 clinical medicine 030225 pediatrics medicine Surgery Neurology (clinical) Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry. 86:e4.77-e4 |
| ISSN: | 1468-330X 0022-3050 |
| Popis: | IntroductionThe aim was to compare evoked potentials (EP) from the P300 paradigm against mismatch negativity (MMN) paradigm, both recorded in the subthalamic nucleus (STN), internal globus pallidus (GPi) and thalamus (Th) and thus electrophysiologically isolate conscious cognition component in these structures.MethodsWe included 8 patients in Deep brain stimulation program and recorded EP (patients with Parkinson's disease, Generalized dystonia, Essential tremor, Epilepsy). The two four-contacts intracerebral electrodes were implanted into the left and right STN, GPi or Th bilaterally. We computed local potentials on the left and right electrode and we studied the latency of cognitive response (from 200 to 400 ms).ResultsIn the comparison of infrequent stimuli related P300 and MMN a significant difference was found in 14 from 16 electrodes. Comparing frequent answers we found significant difference in 13 from 16 electrodes.ConclusionThe difference between evoked potentials of MMN and P300 protocols in 200–400 ms latency suggests that STN, GPi and Th are involved in conscious cognitive processes at the time of stimuli application. |
| Databáze: | OpenAIRE |
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