Gas aggregated Ag nanoparticles as the inorganic matrix for laser desorption/ionization mass spectrometry
| Autor: | Petr Sezemský, Peter Kúš, Vítězslav Straňák, Filip Dycka, Ondřej Kylián, Jiří Kratochvíl, Ján Štěrba, Vadym Prysiazhnyi |
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| Rok vydání: | 2021 |
| Předmět: |
Detection limit
Analyte Materials science Analytical chemistry General Physics and Astronomy 02 engineering and technology Surfaces and Interfaces General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Mass spectrometry Laser 01 natural sciences Silver nanoparticle 0104 chemical sciences Surfaces Coatings and Films law.invention Matrix (chemical analysis) law Desorption Ionization 0210 nano-technology |
| Zdroj: | Applied Surface Science. 541:148469 |
| ISSN: | 0169-4332 |
| Popis: | We report here on a nanoparticle-assisted laser desorption/ionization time-of-flight mass spectrometry (NP-LDI-TOF MS) for the detection of small molecules. This technique is based on the overcoating of a dried analyte by an array of silver nanoparticles produced by gas aggregation source. This allows for the spatially homogeneous distribution of nanoparticles over the analyte that may fully substitute a conventional organic matrix routinely used for the matrix-assisted laser desorption/ionization mass spectrometry and thus limit the possible interference of matrix with the low-mass molecules. Furthermore, it is shown that the intensity of the detected signal strongly correlates with the number of deposited Ag nanoparticles. At its optimum, that was found to correspond to the nanoparticle surface density of 3x103 NPs.µm−2, the detection limit was 3x10-8 g.L-1 for riboflavin. Such a high detection limit, together with good reproducibility, excellent signal stability, and imaging capability, makes this technique a valuable alternative to other laser desorption/ionization-based detection methods. |
| Databáze: | OpenAIRE |
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