Diagnosis of Helicobacter pylori in Bleeding Peptic Ulcer Patients, Evaluation of Urea-Based Tests
| Autor: | Jan Lindebjerg, Ove B. Schaffalitzky de Muckadell, Annmarie Touborg Lassen, Mette Wildner-Christensen |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Breath test
medicine.medical_specialty medicine.diagnostic_test biology business.industry Peptic Spirillaceae Gastroenterology Case-control study Helicobacter pylori medicine.disease biology.organism_classification digestive system diseases chemistry.chemical_compound chemistry Internal medicine Peptic ulcer Predictive value of tests medicine Urea business |
| Zdroj: | Digestion. 66:9-13 |
| ISSN: | 1421-9867 0012-2823 |
| DOI: | 10.1159/000064421 |
| Popis: | Background/Aims: The prevalence of Helicobacter pylori (Hp) has been reported to be lower in patients with bleeding peptic ulcers than in patients with nonbleeding peptic ulcers. This might be due to inaccuracy of the urease-based diagnostic tests when used in patients with bleeding peptic ulcers. The aims of this study were to compare the validity of the rapid urease test (RUT) and 13C-urea breath test in patients with bleeding (group 1) and nonbleeding peptic ulcers (group 2) and to examine whether the presence of blood in the stomach influences the validity of urease-based tests. Methods: 95 consecutive patients with bleeding peptic ulcers (48 with and 47 without blood in the stomach) and 44 with uncomplicated peptic ulcers. Biopsies for RUT and histology were obtained during endoscopy. After endoscopy a 13C-urea breath test was performed. Positive histology was used as ‘gold standard’ defining positive Hp-status. Results: The prevalence of Hp-infection was 44/95 (46%) in group 1 and 29/44 (66%) in group 2 (p = 0.04). The sensitivities and specificities of RUT, 13C-urea breath test and serology (control) were between 0.72 and 0.96; no difference was found between the groups. In group 1 the sensitivity of the RUT decreased from 0.96 when no blood was present to 0.60 when blood was present (p = 0.006). The sensitivity of 13C-urea breath test was not affected by blood in the stomach. Conclusion: When comparing patients with bleeding and nonbleeding peptic ulcers, we did not find any difference in either sensitivity or specificity of the diagnostic tests for Hp. However, the sensitivity of the RUT was lower when blood was present in the stomach, which was the case in only half of the patients. The sensitivity and specificity of the 13C-urea breath test was not affected by the presence of blood in the stomach. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|