Bacterial adherence to ofloxacin-blended polylactone-coated self-reinforced l-lactic acid polymer urological stents
| Autor: | Martti Talja, P. Törmälä, M. Multanen, S. Hallanvuo, Teuvo L.J. Tammela, Tero Välimaa, A. Siitonen, Jukka Seppälä |
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| Rok vydání: | 2001 |
| Předmět: |
biology
Biocompatibility business.industry Urology medicine.medical_treatment Stent biochemical phenomena metabolism and nutrition engineering.material Bacterial growth equipment and supplies bacterial infections and mycoses biology.organism_classification Proteus mirabilis Enterococcus faecalis Microbiology Coating engineering Medicine heterocyclic compounds Ofloxacin business medicine.drug Antibacterial agent |
| Zdroj: | BJU International. 86:966-969 |
| ISSN: | 1464-410X 1464-4096 |
| Popis: | Objective To determine whether ofloxacin coating has any effect on bacterial adherence to bioresorbable self-reinforced l-lactic acid polymer (SR-PLLA) urological stents. Materials and methods SR-PLLA stents were coated with e-caprolactone/l-lactide copolymer blended with ofloxacin at three different concentrations of ofloxacin (0.5, 2 and 5% w/w). The adherence of five bacterial strains (Pseudomonas aeruginosa, Enterococcus faecalis, Proteus mirabilis and two strains of Escherichia coli) to the coated SR-PLLA stents was analysed. Uncoated stent pieces were used as controls. The effect of ofloxacin coating on bacterial growth in the microenvironment of the stent pieces was also analysed. Results Ofloxacin coating prevented bacterial adherence to SR-PLLA stent material; this effect correlated significantly with the ofloxacin concentration of the caprolactone coating. Ofloxacin coating reduced the amount of bacteria in the microenvironment of the stent, but because of natural resistance, ofloxacin coating had little effect on E. faecalis. Conclusion Except for E. faecalis, ofloxacin coating may reduce stent-associated infections. However, further studies are needed to confirm its biocompatibility and efficacy in clinical use. |
| Databáze: | OpenAIRE |
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