An expeditious synthetic route to proteomimetic foldamers

Autor:	Ishu Saraogi, Bapurao A. Bhoge, Vaibhav V Karekar
Rok vydání:	2019
Předmět:	Thesaurus (information retrieval) Chemistry Materials Chemistry 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 0210 nano-technology 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences
Zdroj:	New Journal of Chemistry. 43:556-560
ISSN:	1369-9261 1144-0546
DOI:	10.1039/c8nj04758h
Popis:	α-Helix proteomimetics such as oligobenzamides have been shown to successfully inhibit a broad array of protein–protein interactions (PPIs) mediated by α-helices. Here we report the synthesis of a protected oligobenzamide intermediate, which can be selectively deprotected and alkylated with desired side chains to rapidly afford a library of α-helix proteomimetics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::22fbba4ebdf1bc98d8494e5b8997af7d https://doi.org/10.1039/c8nj04758h Zobrazit plný text záznamu