| Autor: |
Rennos Fragkoudis, Andres Merits, Steven R. Bryden, Daniella A. Lefteri, Georgi Georgiev, Paola Campagnolo, Emilie Pondeville, Margus Varjak, Kave Shams, Robert M. Waterhouse, Emily F Beswick, Stephen Griffin, Sandra Terry, Marleen Van der Laan, Valeria Mastrullo, Marieke Pingen, Clive S. McKimmie |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.1101/2021.02.19.431961 |
| Popis: |
SummaryViruses transmitted byAedesmosquitoes constitute an increasingly important global health burden. Defining common determinants of host susceptibility to this large group of heterogenous pathogens are key for informing the rational design of new pan-viral medicines. Infection of the vertebrate host with these viruses is enhanced by the presence of mosquito saliva, a complex mixture of salivary gland-derived factors and microbiota. We show that enhancement of infection by saliva was dependent on vascular function and was independent of most anti-saliva immune responses, including to salivary microbiota. Instead, theAedesgene product sialokinin mediated enhancement of virus infection through a rapid reduction in endothelial barrier integrity. Sialokinin is unique within the insect world as having vertebrate-like tachykinin sequence and is absent from non-vector competentAnophelesmosquitoes, whose saliva was not pro-viral and did not induce similar vascular permeability. Therapeutic strategies targeting sialokinin have potential to limit disease severity following infection withAedesmosquito-borne viruses. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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