| Autor: |
Youngjoo Lee, Mark Hurtig, Yifan Yu, April D. Pyle, Svenja Hinderer, Yucheng Lin, Jade Tassey, Ruzanna Shkhyan, Dawei Geng, Arijita Sarkar, Liming Wang, Frank A. Petrigliano, Gabriel B. Ferguson, Ben Van Handel, Jacob Bogdanov, J. Gage Crump, Jay R. Lieberman, Kuo-Chang Tseng, Denis Evseenko, Aaron Kavanaugh, Siyoung Lee, Fabrizio Billi, Katja Schenke-Layland, Nancy Q. Liu, Liangliang Li, Jiankang Zhang |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
Osteoarthritis (OA) impacts hundreds of millions of people worldwide, with those affected incurring significant physical and financial burdens. Injuries such as focal defects to the articular surface are a major contributing risk factor for the development of OA. Current cartilage repair strategies are moderately effective at reducing pain but often replace damaged tissue with biomechanically inferior fibrocartilage. Here we describe the development, transcriptomic ontogenetic characterization and quality assessment at the single cell level, as well as the scaled manufacturing of an allogeneic human pluripotent stem cell-derived articular chondrocyte formulation that exhibits long-term functional repair of porcine articular cartilage. These results define a new potential clinical paradigm for articular cartilage repair and mitigation of the associated risk of OA. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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