Exhaustive N-tert-butylation of tetrazoles in thet-BuOH-HBF4 system

Autor:	I. I. Maruda, Yu. V. Grigor'ev, Pavel N. Gaponik, T. N. Andreeva
Rok vydání:	1995
Předmět:	chemistry.chemical_compound chemistry Stereochemistry Organic Chemistry Atom (order theory) Alcohol Tetrazole Formazan Medicinal chemistry
Zdroj:	Chemistry of Heterocyclic Compounds. 31:797-802
ISSN:	1573-8353 0009-3122
DOI:	10.1007/bf01170739
Popis:	Tetrazole and its N-monosubstituted and C,N-disubstituted derivatives in a 48% HBF4 medium react with tertbutyl alcohol, forming the corresponding tetrazolium salts. In this case, tert-burylation of 2-monosubstituted and 2,5-disubstituted tetrazoles occurs at the N(4) atom, as in the case of other allcylating agents; the 1-substituted isomers, in contrast, are quaternized preferentially at the less basic atom N(3), while the 1,5-disubstituted isomers are quaternized exclusively at the N(3) atom.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::22ee9c7365840d71e1a32f29c92b342d https://doi.org/10.1007/bf01170739 Zobrazit plný text záznamu Full text from SpringerLink