Lessons from oncology to understand and treat pulmonary hypertension

Autor:	S. Adnot, S. Eddahibi
Rok vydání:	2007
Předmět:	Oncology Pathology medicine.medical_specialty business.industry General Medicine medicine.disease Pulmonary hypertension Phenotype Smooth muscle Internal medicine medicine.artery Cancer cell Pulmonary artery medicine business
Zdroj:	International Journal of Clinical Practice. 61:19-25
ISSN:	1368-5031
DOI:	10.1111/j.1742-1241.2007.01618.x
Popis:	Summary Pulmonary artery hypertension (PAH) is now considered to be a proliferative disorder characterised by unexplained proliferation of pulmonary artery smooth muscle cells (PA-SMCs) and pulmonary artery endothelial cells (PA-ECs). An abnormal phenotype of PA-SMCs and PA-ECs has been described in PAH and some analogies now appear between pulmonary vascular cells from patients with PAH and cancer cells. Such analogies are discussed here with respect to essential hallmarks of cancer cells and with the hope that new treatments targeted at one or more of these cancer cell abnormalities may be appropriate for PAH.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::22e7cec50ae61e5deb925e92ea690cfb https://doi.org/10.1111/j.1742-1241.2007.01618.x Zobrazit plný text záznamu