Cystatin-C a sensitive diagnostic marker for evaluation of the renal function in patients with cisplatin based chemotherapy
| Autor: | M. Pelzer, Stephan Gripp, Matthias Peiper, Wilfried Budach, Christian Giro, Edwin Bölke, Christiane Matuschek |
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| Rok vydání: | 2008 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty medicine.medical_treatment Urology Renal function EDTA Clearance urologic and male genital diseases chemistry.chemical_compound Internal medicine Medicine In patient reproductive and urinary physiology Cisplatin Creatinine Chemotherapy biology business.industry female genital diseases and pregnancy complications chemistry Cisplatin based chemotherapy Cystatin C biology.protein business medicine.drug |
| Zdroj: | Journal of Clinical Oncology. 26:13520-13520 |
| ISSN: | 1527-7755 0732-183X |
| Popis: | 13520 Background: Cystatin C has recently been proposed as an ideal marker for glomerular filtration rate (GFR). In this pilot study, cystatin C serum levels were evaluated in comparison to serum creatinine concentrations and plasma clearance of chromium 51-labeled EDTA (Cr-EDTA), in patients with advanced head and neck carcinoma receiving cisplatin-based chemotherapy to assess the validity of cystatin C as an alternative endogenous marker of GFR. Methods: Blood samples for the assessment of cystatin C, creatinine and chromium 51 clearances were collected in patients before and after application of cisplatin. Overall, 35 patients were included in the study, 22 of them were eligible receiving cisplatin -based chemotherapy schedules. Results: A 18% increase of cystatin C serum levels was demonstrated after application of cisplatin. Analysis of chromium 51-labeled EDTA clearance revealed a 21% loss of GFR. In contrast, significant changes could not be detected by analysis of serum creatinine levels. Conclusi... |
| Databáze: | OpenAIRE |
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