Difurocoumarins, Psoralen Analogs: Synthesis and DNA Photobinding

Autor:	Francesco Dall'Acqua, Paolo Rodighiero, Anne C. E. Moor, Sergio Caffieri, Adriano Guiotto, Gerard M. J. Beijersbergen van Henegouwen, Adriana Chilin
Rok vydání:	1995
Předmět:	chemistry.chemical_compound Furocoumarins Chemistry Stereochemistry General Chemistry Cycloaddition DNA Psoralen
Zdroj:	Zeitschrift für Naturforschung B. 50:1257-1264
ISSN:	1865-7117 0932-0776
DOI:	10.1515/znb-1995-0821
Popis:	A new tetracyclic derivative, difurocoumarin, was synthesized and studied in order to ascertain its possible use as a photochemotherapeutic agent alternative to psoralens. The compound proved able to photobind monofunctionally to DNA on irradiation with UV-A. A photocycloadduct with thymine was isolated and characterized spectroscopically.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::22e34bb27ae626ff73111cf1fa3964be https://doi.org/10.1515/znb-1995-0821 Zobrazit plný text záznamu