| Autor: |
W. Becher, H. Stelzer, W. Kraft-Weyrather, S. Ritter, Gerhard Kraft, Hans Geissel, Dieter Schardt, K. Blasche, B. Fischer, G. Gademann, J. Klabunde, G. Münzenberg, W. Rösch, D. Böhne, Th. Schwab, B. Langenbeck, Th. Haberer |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
International Journal of Radiation Applications and Instrumentation. Part D. Nuclear Tracks and Radiation Measurements. 19:911-914 |
| ISSN: |
1359-0189 |
| DOI: |
10.1016/1359-0189(91)90340-n |
| Popis: |
The use of heavy charged particles in radiotherapy has two major advantages: Firstly, particle beams exhibit a superior dose distribution because of reduced lateral scattering, the finite range of the particles and the increased dose deposition towards the end of the particle track. Secondly, heavy ions exhibit an increased biological efficiency in the region of the increased energy deposition. This diminishes the differences in the radio response between well oxygenated and hypoxic cells as well as differences between fast and slowly proliferating cells. In addition, with high values for relative biological efficiencies, the repair capacity of cells in the tumor are selectively reduced. Both effects, the high energy deposition and the increased RBE values at the end of the particle tracks, are due to the different interaction mechanism of heavy ions with the target material and open a new field of precision and efficiency in radiotherapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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