Investigations in the 4-aryl-5-arylamino-1,2,4-triazoline-3-thione series

Autor:	I. M. Bazavova, R. G. Dubenko, P. S. Pel'kis
Rok vydání:	1971
Předmět:	chemistry.chemical_classification Aryl Organic Chemistry chemistry.chemical_element MONOCHLOROACETIC ACID Alkylation Sulfur Medicinal chemistry Nitrogen chemistry.chemical_compound chemistry Nitrogen atom Organic chemistry Thioamide Methyl iodide
Zdroj:	Chemistry of Heterocyclic Compounds. 7:121-124
ISSN:	1573-8353 0009-3122
DOI:	10.1007/bf00477966
Popis:	Cyanoethylation of 4-aryl-5-arylamino-1,2,4-triazoline-3-thiones proceeds at the nitrogen atom of the thioamide group. Alkylation of 4-aryl-5-arylamino-1,2,3-triazoline-3-thiones with chloroacetonitrile, monochloroacetic acid and its ester, Β-chloropropionic acid, and methyl iodide proceeds at the sulfur atom. The acidity constants of substituted 4-phenyl-5-phenylamino-1,2,4-triazoline-3-thiones differ by two orders of magnitude from the acidity constants of the more acidic substituted 4-phenyl-1,2,4-triazoline-3-thiones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::22c9c66f8931a20783ca46a0e36cfdfa https://doi.org/10.1007/bf00477966 Zobrazit plný text záznamu Full text from SpringerLink