ANTIOXIDANT SAFFRON CONSTITUENTS BIND DNA AND TRNA

Autor:	H.A. Tajmir-Riahi, Moschos G. Polissiou, Petros A. Tarantilis, C.D. Kanakis
Rok vydání:	2010
Předmět:	Antioxidant ved/biology DPPH medicine.medical_treatment ved/biology.organism_classification_rank.species Crocetin RNA Horticulture Biology Safranal chemistry.chemical_compound Biochemistry chemistry Crocus sativus medicine Binding site DNA
Zdroj:	Acta Horticulturae. :217-222
ISSN:	2406-6168 0567-7572
DOI:	10.17660/actahortic.2010.850.36
Popis:	Crocetin (CRT) and dimethylcrocetin (DMCRT) are derived from saffron's carotenoids while safranal is the main component of its essential oil. The antioxidant activity of these compounds was tested by the DPPH antioxidant activity assay. Also the interactions of CRT, DMCRT and safranal with calf-thymus DNA and transfer RNA in aqueous solution at physiological conditions are reported. The structural analysis showed external binding to the major or minor groove and some degree of intercalation of saffron compounds to DNA and RNA. A partial B- to A-DNA transition occurs at high ligand concentration while tRNA remains in the A-family.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::22c29c4d0cffe01951964baffadfa867 https://doi.org/10.17660/actahortic.2010.850.36 Zobrazit plný text záznamu