Inhibition of repolarizing ionic currents by drugs

Autor:	D. Escande
Rok vydání:	2001
Předmět:	Drug Heart disease business.industry Medical screening media_common.quotation_subject Pharmacological Substance Pharmacology Cardiac repolarization medicine.disease Sudden death Human use cardiovascular system medicine Repolarization Cardiology and Cardiovascular Medicine business media_common
Zdroj:	European Heart Journal Supplements. 3:K17-K22
ISSN:	1520-765X
DOI:	10.1016/s1520-765x(01)90002-1
Popis:	Every pharmacological substance that prolongs cardiac repolarization produces a risk of serious ventricular arrhythmias leading eventually to sudden death. Numerous non-cardiovascular drugs already in the market have been associated with altered cardiac repolarization and proarrhythmic eects. Because this side e ect is serious (albeit infrequent), every new chemical entity intended for human use should be screened during the preclinical stages of its pharmaceutical development. Various in vitro and in vivo models have been established to accomplish this screen. Standard procedures are now available to prevent that drugs non-intentionally aecting cardiac repolarization will be developed and launched in the future.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::22bbaaeaa4a6ab8e83205f3ab32fd8a9 https://doi.org/10.1016/s1520-765x(01)90002-1 Zobrazit plný text záznamu