Sugammadex Hypersensitivity—A Case of Anaphylaxis

Autor:	Van Wijk R, Kuruppu P, Nanjappa N, Jeyadoss J
Rok vydání:	2014
Předmět:	Saline control Resuscitation business.industry Critical Care and Intensive Care Medicine medicine.disease Sugammadex Mast cell tryptase Anesthesiology and Pain Medicine Negative response Anesthesia Allergy test medicine Abdominal aneurysm business Anaphylaxis medicine.drug
Zdroj:	Anaesthesia and Intensive Care. 42:89-92
ISSN:	1448-0271 0310-057X
DOI:	10.1177/0310057x1404200115
Popis:	We describe a case of a patient undergoing open abdominal aneurysm surgery who developed a severe, life-threatening allergic reaction immediately after administration of sugammadex. The manifestation was purely a cardiovascular collapse. The mainstay of treatment was administration of high-dose adrenaline and fluid resuscitation. The diagnosis of anaphylaxis was supported by a positive serum mast cell tryptase (93 µg/l) at one hour post-event. Sugammadex was confirmed as the cause of the anaphylaxis by a positive intradermal allergy test (25 mm diameter response to 1:100 dilution), with a normal saline control and a negative response to the other drugs used during the event. This case report is a reminder that the use of sugammadex is associated with rare but serious risks.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::22b8316f691d5379e74d7d6b80e47a50 https://doi.org/10.1177/0310057x1404200115 Zobrazit plný text záznamu