Asymmetric phase-transfer mediated epoxidation of α,β-unsaturated ketones using catalysts derived from Cinchona alkaloids

Autor:	P. G. Wainwright, Barry Lygo
Rok vydání:	1998
Předmět:	biology Organic Chemistry Enantioselective synthesis Cinchona Cinchona Alkaloids biology.organism_classification Biochemistry Catalysis chemistry.chemical_compound chemistry Phase (matter) Sodium hypochlorite Drug Discovery Organic chemistry Ammonium
Zdroj:	Tetrahedron Letters. 39:1599-1602
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(97)10779-1
Popis:	The enantioselective epoxidation of α,β-unsaturated ketones utilising Cinchona alkaloid-derived quaternary ammonium phase-transfer catalysts bearing an N-anthracenylmethyl function are presented. It has been found that the O-benzyl derivatives of these catalysts in conjunction with sodium hypochlorite give high stereocontrol and application of this process to the enantioselective synthesis of a range of trans-α,β-epoxy ketones (e.e. 69–89%) is presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::22a7937ce9438e3e5682ed1f485d49eb https://doi.org/10.1016/s0040-4039(97)10779-1 Zobrazit plný text záznamu Full Text from ScienceDirect