Serum levels of matrix metalloproteinase-2 in patients with oral submucous fibrosis and oral squamous cell carcinoma

Autor:	Pooja Kherde, Suchitra Gosavi
Rok vydání:	2020
Předmět:	stomatognathic diseases medicine.medical_specialty Oral submucous fibrosis business.industry Internal medicine medicine Basal cell In patient Matrix metalloproteinase medicine.disease business Gastroenterology
Zdroj:	International Journal of Research in Medical Sciences. 8:636
ISSN:	2320-6012 2320-6071
DOI:	10.18203/2320-6012.ijrms20200248
Popis:	Background: Matrix metalloproteinase-2 (MMP-2), which is supposed to enable cancer cells cross the basement membrane and metastasize by selectively cleaving type IV collagen, is anticipated to be a good diagnostic and prognostic marker in oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSMF). Thus, the study is aimed to estimate and compare the serum MMP-2 levels in patients with OSMF and OSCC.Methods: The study was conducted on 88 subjects, divided into three groups; Group I (healthy subjects, n=28), Group II (patients with OSMF, n=30), and Group III (patients with OSCC, n=30). Serum levels of MMP-2 were estimated and compared among the groups and further with the clinical parameters within the groups.Results: The mean serum MMP-2 levels in patients with OSMF (2.87±1.04 ng/mL) and with OSCC (11.55±2.16 ng/mL) were significantly higher than the healthy subjects (0.93±0.26 ng/mL) (p
Databáze:	OpenAIRE
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