Anti-inflammatoire non stéroïdien et inhibiteur de l'enzyme de conversion : association dangereuse en période postopératoireal
| Autor: | A Aouifi, C. Boucaud, C Chambrier, Paul Boulétreau, C Badid |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Efferent arteriole
medicine.medical_specialty biology business.industry Renal function Angiotensin-converting enzyme General Medicine Pharmacology urologic and male genital diseases medicine.disease Nephrotoxicity Anesthesiology and Pain Medicine Endocrinology medicine.anatomical_structure Quinapril Internal medicine Renal blood flow ACE inhibitor medicine biology.protein cardiovascular diseases business Kidney disease medicine.drug |
| Zdroj: | Annales Françaises d'Anesthésie et de Réanimation. 16:55-57 |
| ISSN: | 0750-7658 |
| DOI: | 10.1016/s0750-7658(97)84279-7 |
| Popis: | A 72-year-old man experienced a postoperative acute renal failure (ARF) from a nonsteroidal anti-inflammatory drug (NSAID) and an angiotensin converting enzyme inhibitor (ACEI) intake and promoted by an unrecognized myeloma, peroperative hypotension and hormonal response to surgical stress. This drug combination can result in ARF through a fall of glomerular filtration by combined renal blood flow changes: NSAID inhibit vasodilation by renal prostaglandins, and the vasoconstrictor effect on the efferent arteriole is inhibited by the ACEI. Nephrotoxicity during the simultaneous use of ACEI and NSAID is increased by other risk factors of renal insufficiency such as ageing, preexisting renal disease and hypovolaemia. In these cases, a preventive therapy should be considered. |
| Databáze: | OpenAIRE |
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