Triazole-chalcones: Lack of antibacterial, anti-candida, and anti-dengue virus activities
| Autor: | Karina Marjorie Silva Herrera, Felipe Rocha da Silva Santos, Alex Gutterres Taranto, Michelli dos Santos, Jéssica Tauany Andrade, Jamária Adriana Pinheiro Soares-Martins, Luciana Lara dos Santos, Lailah Horácio Sales Pereira, Ariane Coelho Ferraz, William Gustavo Lima, Jaqueline Maria Siqueira Ferreira, Marina Goulart da Silva, José Carlos de Magalhães, José A.F.P. Villar |
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| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
biology 010405 organic chemistry Chemistry Broth microdilution Triazole Pharmaceutical Science biology.organism_classification Antimicrobial 01 natural sciences 0104 chemical sciences Acinetobacter baumannii Microbiology 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Staphylococcus epidermidis Drug Discovery Candida albicans Antibacterial activity Enterobacter cloacae |
| Zdroj: | Journal of Pharmaceutical Negative Results. 9:39 |
| ISSN: | 0976-9234 |
| Popis: | Background: The need to identify new antimicrobial drugs that present different mechanisms of action is urgent. The variety of biological properties of chalcones give them a potential therapeutic compounds. Chalcones' synthetic manipulations are investigated worldwide in search of more powerful and efficient drugs to several infectious diseases' treatment. Objective: The purpose of this work was to evaluate the potential antibacterial, antifungal, and anti-dengue virus (DENV) of new ten triazole chalcones. Materials and Methods: Triazole chalcones were used to determine its antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), Gram-negative bacteria (Klebsiella pneumoniae, Enterobacter cloacae, Acinetobacter baumannii, and Pseudomonas aeruginosa) species, and anti-Candida activity (Candida albicans) by the broth microdilution assay. The anti-DENV activity was evaluated by cell viability quantification after viral infection by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay. Results: Although Triazole chalcones have shown a low cytotoxicity concentration (with CC50of 47.21–192.51 μg/mL), these compounds did not exhibit antimicrobial activity against Gram-negative and Gram-positive bacteria, C. albicans neither DENV, even in the highest concentration tested. Triazole chalcones had no activity against all tested microorganisms, except for Gram-positive S. epidermidis bacteria when a poor antimicrobial effect was observed (125 μg/mL). Conclusion: The results suggest that triazole chalcones investigated in this study are not promising antimicrobial agents. |
| Databáze: | OpenAIRE |
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