Water-mediated and promoted eco-friendly one-pot synthesis of azaarene substituted isoxazoles
| Autor: | D. Nagaraju, Eligeti Rajanarendar, Modugu Nagi Reddy, Pittala Praveen Kumar |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
010405 organic chemistry
One-pot synthesis Substrate (chemistry) General Chemistry 010402 general chemistry 01 natural sciences Environmentally friendly Catalysis 0104 chemical sciences Solvent chemistry.chemical_compound chemistry Electrophile Materials Chemistry Michael reaction Organic chemistry Isoxazole |
| Zdroj: | New Journal of Chemistry. 41:4783-4787 |
| ISSN: | 1369-9261 1144-0546 |
| DOI: | 10.1039/c7nj01165b |
| Popis: | An efficient and green approach for the sp3 C–H bond functionalization of 2-methyl azaarenes to 3-methyl-4-nitro-5-styrylisoxazoles in water has been described. Nitrostyrylisoxazoles were proven to be good CC electrophilic acceptors for the construction of various azaarene-containing Michael addition products. This method provides an efficient and environmentally benign method for the one-pot synthesis of biologically important azaarene-substituted isoxazole derivatives in good yields. The important aspects of the present methodology are the use of non-toxic solvent, that it is catalyst free, the ease of purification and the large substrate scope. |
| Databáze: | OpenAIRE |
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