AGE-RELATED AND STRESS-INDUCED PROTEINOPATHY OF CEREBRAL NEURONS IN RATS

Autor:	O N Antoshkin, V L Zagrebin, A S Egorova, A V Terentiev, S A Sargsyan, O V Fedorova
Rok vydání:	2015
Předmět:	Pathology medicine.medical_specialty Amyloid Neurodegeneration Protein metabolism Biology medicine.disease Somatosensory system chemistry.chemical_compound medicine.anatomical_structure chemistry Cerebral cortex Apoptosis medicine Extracellular Neuron
Zdroj:	I.P. Pavlov Russian Medical Biological Herald. 23:7-10
ISSN:	2500-2546 0204-3475
DOI:	10.17816/pavlovj201537-10
Popis:	A study of morphological and functional changes in neurons and glial cells of the cerebral cortex of white rats at the stages of aging and stress-induced neurodegeneration under experiment was investigated. It was found that the age-related neurodegenerative changes in somatosensory cortex neurons of white rats at the age of 30 months are characterized with pronounced signs of proteoinopathy and developing of apoptosis, which is enhanced by exposure to stress factors in clear violation of protein metabolism in the form of accumulation of intra- and extracellular amyloid.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::229a0a486c64b782bf643db50914f2a0 https://doi.org/10.17816/pavlovj201537-10 Zobrazit plný text záznamu