Ectopic ACTH syndrome due to salivary gland adenoid cystic carcinoma
| Autor: | Sugawara M, Hagen Ga |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
endocrine system
medicine.medical_specialty Metyrapone business.industry Urinary system medicine.disease Hypokalemia Salivary Gland Adenoid Cystic Carcinoma Cytosol Cushing syndrome Endocrinology Internal medicine Ectopic ACTH syndrome Internal Medicine medicine medicine.symptom business hormones hormone substitutes and hormone antagonists Dexamethasone medicine.drug |
| Zdroj: | Archives of Internal Medicine. 137:102-105 |
| ISSN: | 0003-9926 |
| DOI: | 10.1001/archinte.137.1.102 |
| Popis: | A 68-year-old woman developed Cushing syndrome associated with a submaxillary salivary gland adenoid cystic carcinoma. High levels of immunoreactive adrenocorticotrophic hormone (ACTH) were found in the tumor and peripheral blood. Urinary 17-hydroxycorticosteroid levels decreased following administration of dexamethasone, suggesting possible suppression of ectopic ACTH production. however, there was no specific in vitro binding of dexamethasone by tumor cytosol. A trial of metyrapone therapy resulted in control of hypokalemia and hyperglycemia. Both plasma cortisol and 11-deoxycortisol levels decreased with metyrapone administration, suggesting that this agent may inhibit not only 11-beta-hydroxylation, but also possibly earlier steps in glucocorticoid synthesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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