Organocatalytic Enantioselective Approach to Spirocyclic Δβ,γ-Butenolides

Autor:	Łukasz Albrecht, Dorota Kowalczyk, Joanna Hejmanowska, Marek Dzięgielewski
Rok vydání:	2014
Předmět:	Diphenylprolinol Chemistry Stereochemistry Organic Chemistry medicine Enantioselective synthesis medicine.drug
Zdroj:	Synlett. 25:2957-2961
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0034-1378905
Popis:	A novel method for the preparation of the spirocyclic Δβ,γ-butenolides is presented. The developed strategy is based on a trienamine-mediated [4+2]-cycloaddition between (E)-3-alkylidene-5-arylfuran-2(3H)-ones and 2,4-dienals. Target products containing three contiguous centres including one quaternary are efficiently formed in a highly enantiomerically enriched form in the presence of the silyl-protected diphenylprolinol aminocatalyst.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::229199a7e46cc6e967d5689f3ceafe21 https://doi.org/10.1055/s-0034-1378905 Zobrazit plný text záznamu