An Efficient Synthesis of (2S,6S)- and meso-Diaminopimelic Acids via Asymmetric Hydrogenation
Autor: | Wei Wang, Jianqing Yang, Victor J. Hruby, Chiyi Xiong |
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Rok vydání: | 2004 |
Předmět: | |
Zdroj: | Synthesis. 2002 |
ISSN: | 1437-210X 0039-7881 |
Popis: | An efficient synthesis of the title compounds l and 2 has been successfully developed. The key step is the asymmetric hydrogenation of dehydroamino acid 7 using [Rh(I)(COD)-(S,S) or -(R,R)-Et-DuPHOS)] + OTf to produce the optically active, protected amino acid derivatives in high ee (>95%) The approach also can he used for the synthesis of other isomers and analogues. |
Databáze: | OpenAIRE |
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