An Efficient Synthesis of (2S,6S)- and meso-Diaminopimelic Acids via Asymmetric Hydrogenation

Autor:	Wei Wang, Jianqing Yang, Victor J. Hruby, Chiyi Xiong
Rok vydání:	2004
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Stereochemistry Organic Chemistry Asymmetric hydrogenation Optically active DuPhos Catalysis Amino acid
Zdroj:	Synthesis. 2002
ISSN:	1437-210X 0039-7881
Popis:	An efficient synthesis of the title compounds l and 2 has been successfully developed. The key step is the asymmetric hydrogenation of dehydroamino acid 7 using [Rh(I)(COD)-(S,S) or -(R,R)-Et-DuPHOS)] + OTf to produce the optically active, protected amino acid derivatives in high ee (>95%) The approach also can he used for the synthesis of other isomers and analogues.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2283a9d23e4b3e7dc7979b7558d87a79 https://doi.org/10.1055/s-2002-19295 Zobrazit plný text záznamu