Dimethylheptyl [3-(N-hetaryl)propyl]silanes: Synthesis, antimicrobial and antiblastic activity

Autor:	V. Verovsky, R. Sturkovich, S. Deineka, Yu. Sh. Gol'dberg, Edmunds Lukevics, N. Prodanchuk, I. Augustane
Rok vydání:	1989
Předmět:	Inorganic Chemistry chemistry.chemical_compound Silanes chemistry Yield (chemistry) Organic chemistry Tetrazole General Chemistry Alkylation Antimicrobial Silane Catalysis
Zdroj:	Applied Organometallic Chemistry. 3:393-399
ISSN:	1099-0739 0268-2605
DOI:	10.1002/aoc.590030504
Popis:	The alkylation of monoazoles, diazoles, triazoles and tetrazoles with dimethylheptyl(3-iodopropyl)silane using liquid/liquid phase-transfer catalysis affords the corresponding [3-(N-azolyl)propyl]silanes in high yield, by which means the nonsymmetric ambident heterocycles 1,2,4-triazole and tetrazole undergo alkylation regiospecifically in position 1 and 2, respectively. Dimethylheptyl[3-(N-imidazolyl)propyl]silane demonstrated high fungistatic activity with respect to S. cerevisiae and T.rubrum in combination with high cytotoxicity.
Databáze:	OpenAIRE
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