Prognostic value of mitochondrial DNA4977 deletion and mitochondrial DNA copy number in patients with stable coronary artery disease
| Autor: | Clara Carpeggiani, Maria Grazia Andreassi, Antonella Mercuri, Andrea Borghini, Eugenio Picano, Silvia Pulignani, Stefano Turchi, Cecilia Vecoli |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Mitochondrial DNA medicine.medical_specialty Proportional hazards model business.industry 030204 cardiovascular system & hematology medicine.disease Peripheral blood Coronary artery disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Increased risk Internal medicine Cohort medicine Cardiology In patient cardiovascular diseases Myocardial infarction Cardiology and Cardiovascular Medicine business |
| Zdroj: | Atherosclerosis. 276:91-97 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2018.07.015 |
| Popis: | Background and aims Mitochondrial DNA copy number (mtDNA-CN) depletion has been recently associated with an increased cardiovascular risk. However, the integrity of mtDNA is another key aspect of the energy metabolism and mitochondrial function. We investigated the prognostic role of peripheral blood common mitochondrial deletion (mtDNA4977) and mtDNA-CN on long-term major adverse cardiac events (MACEs) and all-cause mortality in a cohort of patients with coronary artery disease (CAD). Methods Within the Italian GENOCOR (Genetic Mapping for Assessment of Cardiovascular Risk) cohort, we studied 515 patients (450 males, 65 ± 8 years) with known or suspected stable CAD. mtDNA4977 deletion and mtDNA-CN were assessed in peripheral blood using qRT-PCR. Results During a mean follow-up of 4.5 ± 1.1 years, 78 (15%) patients had MACEs (15 cardiac deaths, 17 nonfatal myocardial infarction and 46 coronary revascularizations) and 28 patients died for non-cardiac causes. Patients with high levels of mtDNA4977 deletion (>75th) had increased risk of MACEs (log rank = 7.2, p=0.007) and all-cause mortality (log rank = 5.7, p=0.01) compared with patients with low mtDNA4977 deletion (≤75th). Multivariate Cox regression analysis showed that log mtDNA4977 was a significant predictor of MACEs (HR = 2.17; 95% CI, 1.31–3.59; p=0.003) and all-cause mortality (HR = 2.03; 95% CI: 1.13–3.65, p=0.02). Log mtDNA-CN was not significantly associated with MACEs or all-cause mortality. However, patients with high mtDNA4977 deletion (>75th) and low mtDNA-CN ( Conclusions Mitochondria DNA damage was associated with an increased risk of MACEs and all-cause mortality in patients with stable CAD, confirming the critical role of mitochondrial dysfunction in atherosclerosis. |
| Databáze: | OpenAIRE |
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