Adamantylimino derivatives of cardenolides

Autor:	Ya. I. Khadzhai, M. V. Mokrouz, V. V. Pavlova, I. F. Makarevich, V. F. Konev
Rok vydání:	1984
Předmět:	Ethanol Plant Science General Chemistry Chloride General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Boiling point Residue (chemistry) chemistry medicine Strophanthidin Methylene medicine.drug Nuclear chemistry
Zdroj:	Chemistry of Natural Compounds. 20:508-509
ISSN:	1573-8388 0009-3130
DOI:	10.1007/bf00574358
Popis:	Strophanthidin (4 g) was dissolved in 50 ml of chloroform--absolute ethanol (3:1) and the resulting solution was treated dropwise with a solution of 1.5 g of l-aminoadamantane in the same mixture of solvents. The reaction was performed at the boiling point of the reaction mixture on the water bath. The course of the reaction was monitored by thin-layer chromatography in the methylene chloride-methanol (@3:7) system. After the end of the reaction (about i0 h), the mixture of solvents was evaporated off in vacuum, and the residue (4.5 g) was dissolved in methylene chloride and crystallized, giving 3.2 g of N-tert-adamantyliminostrophanthidin (I) with bp 250-256/260°C, [a]~ ° +19.7 ° (c 1.0; methylene chloridemethanol (i:i).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::227905873829467fc0328439c5c1c4a1 https://doi.org/10.1007/bf00574358 Zobrazit plný text záznamu Full text from SpringerLink