Effects of a Low Concentration of Ethanol on the Potential Difference of Mucous-Secreting Glands of the Toad Pleurodema thaul
| Autor: | B.C. Norris, J.B. Concha |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Pharmacology
medicine.medical_specialty biology Chemistry ATPase Sodium chemistry.chemical_element General Medicine Toad Apical membrane biology.organism_classification Ouabain Endocrinology Permeability (electromagnetism) Internal medicine biology.animal medicine biology.protein Pleurodema thaul Perfusion medicine.drug |
| Zdroj: | Pharmacology. 22:47-51 |
| ISSN: | 1423-0313 0031-7012 |
| DOI: | 10.1159/000137472 |
| Popis: | The effect of noradrenaline on the bioelectric activity of the mucous glands of 9 toads was studied by means of intraglandular recording. Noradrenaline induced a transient increase in glandular secretion and a simultaneous two-phase increase in the potential difference of the glands. Perfusion with 0.043 mM ethanol-Ringer’s reversibly reduced this response. Ouabain, in concentrations which block Na+K+-activated ATPase, markedly reduced the slow phase of the response of the’ isolated skin to noradrenaline. The results suggest that ethanol acts in two ways: first by increasing the electrical resistance of the skin and secondly by partially inhibiting the active transport of sodium due to a decrease in permeability of the apical membrane of the transporting cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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