Teratogenesis: A statistical structure-activity model

Autor:	Thomas R. Lander, Kurt Enslein, John R. Strange
Rok vydání:	1983
Předmět:	Toxicology Classification rate Quantitative structure–activity relationship Oncology Health Toxicology and Mutagenesis Statistics Genetics Genetics (clinical) Statistical structure Mathematics
Zdroj:	Teratogenesis, Carcinogenesis, and Mutagenesis. 3:289-309
ISSN:	1520-6866 0270-3211
DOI:	10.1002/1520-6866(1990)3:3<289::aid-tcm1770030308>3.0.co;2-3
Popis:	This structure-activity model of teratogenicity was developed to provide the ability to rank untested compounds by their probability of teratogenicity. The model is based on 430 compounds collected from various sources in the literature and scored from zero to one as to evidence of teratogenicity. A discriminant equation then separates those compounds in the extremes of this distribution. The false positive classification rate based on the compounds in the equation is approximately 8% and the false negative rate approximately 10%. Approximately 22% of the compounds are not classifiable as either teratogens or nonteratogens with this equation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2261a2a6035ecbc2e6343461c3baed12 https://doi.org/10.1002/1520-6866(1990)3:3<289::aid-tcm1770030308>3.0.co Zobrazit plný text záznamu Plný text