Serum Alpha 1-Acid Glycoprotein Concentrations in Healthy and Tumor-Bearing Cats

Autor:	K. L. Richardson, Susan E. Lana, Martin J. Fettman, Rodney A. Hansen, Gregory K. Ogilvie, Judy A. Walton, K. L. Mitchener, Kimberly Anne Selting, M. A. Scherk
Rok vydání:	2000
Předmět:	Radial immunodiffusion medicine.medical_specialty CATS General Veterinary biology business.industry Acute-phase protein Alpha (ethology) Orosomucoid Blood proteins Endocrinology Internal medicine medicine biology.protein Round cell business
Zdroj:	Journal of Veterinary Internal Medicine. 14:503-506
ISSN:	1939-1676 0891-6640
Popis:	The purpose of this study was to evaluate alpha 1-acid glycoprotein (AGP) concentrations in tumor-bearing and healthy cats. The hypothesis of the present study was that AGP concentrations would be significantly increased in tumor-bearing cats. Serum from 51 healthy and 97 tumor-bearing, client-owned cats was harvested at the time of presentation and stored at -80 degrees C until assayed. Cats with measurable, histologically confirmed malignancies, and healthy cats of similar ages were included. Serum was assayed for AGP concentration by using a radial immunodiffusion method. AGP concentrations were significantly (P = .0051) higher in tumor-bearing (763 +/- 595 microg/mL; mean +/- SD) when compared to healthy cats (501 +/- 377 microg/mL; mean +/- SD). Of the tumor-bearing cats, 35 had carcinomas, 33 had sarcomas, and 26 had discrete, round cell tumors. AGP concentrations were 645 +/- 62 microg/mL, 660 +/- 540 microg/mL, and 967 +/- 860 microg/mL, respectively, and there were no significant differences among the groups.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::225de2b5f7281719c5fee885f94dda37 https://doi.org/10.1111/j.1939-1676.2000.tb02267.x Zobrazit plný text záznamu Plný text