| Autor: | Zlatnik , Elena Yu., Shulgina , Oksana G., Nepomnyashchaya , Evgeniya M., Zolotareva , Ekaterina I. |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2017 |
| Předmět: | |
| DOI: | 10.23683/0321-3005-2017-4-2-41-47 |
| Popis: | We had achieved antitumor effect after the administration of metallic nanoparticles (NP Cu, NP Zn and NP Fe) on transplanted sarcoma 37 (S37) in tumor-bearing mice in previous studies. The experimental investigation of the effect of the same NP on central (thymus) and peripheral (spleen) organs of immune system was carried out in 40 tumor-bearing mice with the use of morphologic and morphometric methods in the present study. Thymus and spleens of 4 groups of mice were studied: 3 were experimental ones receiving NP Cu, NP Zn and NP Fe, 1 was the control one. Our results showed that the control mice were characterized by morphologic signs of depression and even injure in the studied organs. On the contrary, administration of NP Zn causes stimulation of predominantly T-link of immune system (hyperplasia of cortical sub-stance in thymic lobules); while after injection of NP Cu enhancement of B-link was noted (hyperplasia of spleen follicles and increased incidence of mitosis). Since such changes developed in the context of the transplanted tumor regression they are likely to indicate the involvement of immune system in the effective antitumor response. After injection of NP Fe with poor antitumor effect histological peculiarities of the organs are similar to those of control mice with S37 and are characterized by morphologic signs of inhibition or even destruction. Thus we have showed stimulating effect of NP Cu and NP Zn on organs of immune system in mice with NP-induced regression of transplanted tumor while NP Fe produced no or rather inhibiting effect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|