Structure and antioxidant superoxide dismutase activity of copper(II) hydrazone complexes
| Autor: | Ram N. Patel, Yogendra Singh, Ray J. Butcher, R.K. Bhubon Singh, Pradeep Kumar Vishakarma |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Benzimidazole biology 010405 organic chemistry Chemistry Superoxide Stereochemistry Hydrazone chemistry.chemical_element Bioinorganic chemistry 010402 general chemistry 01 natural sciences Copper Square pyramidal molecular geometry 0104 chemical sciences law.invention Inorganic Chemistry Superoxide dismutase Crystallography chemistry.chemical_compound law Materials Chemistry biology.protein Physical and Theoretical Chemistry Electron paramagnetic resonance |
| Zdroj: | Polyhedron. 122:1-15 |
| ISSN: | 0277-5387 |
| Popis: | Three new mixed ligand hydrazone complexes viz., [Cu(L)(neocuprin)]NO3·H2O 1, [Cu(L)(HL)]ClO4 2 and [Cu2(2-(2-pyridyl)benzimidazole)2(L)2]ClO4 3 (L = N′-[(E)-phenyl(pyridin-2-yl)methylidene]furan-2-carbohydrazide) have been synthesized by the biomimetic synthesis strategy and their structures were determined by single crystals X-ray analysis. The effect of differing contagious, as well as the rotational conformational versatility of HL, was demonstrated by the difference in structures of complexes 1–3. These complexes exhibited the antioxidant superoxide dismutase enzymatic activity. The geometry of copper(II) atom in complex 1 is distorted square pyramidal while in complexes 2 and 3 the geometries around copper(II) atoms are distorted octahedral. Magnetic measurements and epr spectroscopy of binuclear complex 3 have shown antiferromagnetic exchange interaction with a coupling constant (J) = −10.87 cm−1. Electronic and spectral properties of these newly synthesized hydrazone complexes (1–3) are interpreted by DFT and TDDFT calculations. The results reveal that molecular structures have significant effect on antioxidant superoxide activity. Such biological experimental values (antioxidant SOD activity data) are indicative of the promising application of these complexes into the bioinorganic chemistry of superoxide dismutase. |
| Databáze: | OpenAIRE |
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