Schiff-base based hydrogels as degradable platforms for hydrophobic drug delivery
| Autor: | Lyall R. Hanton, Esmat Jalalvandi, Stephen C. Moratti |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Polymers and Plastics General Physics and Astronomy 02 engineering and technology 010402 general chemistry 01 natural sciences chemistry.chemical_compound PEG ratio Polymer chemistry Materials Chemistry medicine Solubility chemistry.chemical_classification Cyclodextrin Organic Chemistry technology industry and agriculture Polymer 021001 nanoscience & nanotechnology Binding constant 0104 chemical sciences Dextran chemistry Self-healing hydrogels Swelling medicine.symptom 0210 nano-technology |
| Zdroj: | European Polymer Journal. 90:13-24 |
| ISSN: | 0014-3057 |
| DOI: | 10.1016/j.eurpolymj.2017.03.003 |
| Popis: | A rapid in-situ forming hydrogel was prepared as a potential carrier for the delivery of hydrophobic drugs. Schiff-base reaction between dextran aldehyde polymer (DA) and cyclodextrin-functionalized polyaspartamide with PEG pendants (PG) formed the gel. Two sets of hydrogels with different cross-linking densities and similar content of cyclodextrin (CD) moieties were prepared and characterized. These hydrogels degraded in less than two weeks and showed no toxicity effects towards the L929 mouse fibroblast cell line. It was found that the cross-linking density was the key factor in the swelling and rheological behaviour of the hydrogels in which the gel with the higher cross-linking density was stiffer and less swellable than the lower cross-linked network. Hydrophilic PEG pendants assisted in linking large amounts of CD functionalities on polyaspartamide without affecting the solubility of the final polymer; while the CD functionalities provided binding sites for the hydrophobic model drug to form CD:drug complexes. The formation of these inclusion complexes was confirmed by phase solubility studies, FTIR, 1H NMR and DSC analyses. Incorporation of CD groups into the polymer led to an increase in the binding constant of the CD:drug inclusion complex. This indicated the polymer had a favourable influence on the degree of binding. The hydrophobic drug loaded into these hydrophilic matrices was released during 5 days from the higher cross-linked network and 4 days from the hydrogel with the lower cross-linking density through a super case ΙΙ mechanism. The microstructure of the hydrogels with or without the model drug was studied by SEM and showed no evidence of non-dissolved or solid particles of the drug. |
| Databáze: | OpenAIRE |
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