| Autor: |
Robert A. Clark, Senlin Li, Kevin G. Leidal, Robert L. Reddick, Doran W. Pearson, Gerene M. Denning, Joshua R. Clark, Karl-Heinz Krause, Anthony J. Valente |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Journal of Biological Chemistry. 277:32369-32378 |
| ISSN: |
0021-9258 |
| DOI: |
10.1074/jbc.m205269200 |
| Popis: |
Induction of differentiation of HL-60 human myeloid cells profoundly affected expression of calreticulin, a Ca(2+)-binding endoplasmic reticulum chaperone. Induction with Me(2)SO or retinoic acid reduced levels of calreticulin protein by approximately 60% within 4 days. Pulse-chase studies indicated that labeled calreticulin decayed at similar rates in differentiated and undifferentiated cells (t(12) approximately 4.6 days), but the biosynthetic rate was |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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