| Autor: |
E.M.G.J. de Jong, A.M. van Oostveen, Patrick L.J.M. Zeeuwen, Irma Joosten, P.C.M. van de Kerkhof, M. den Heijer, M.E.A. de Jager, Judith G.M. Bergboer, Marieke M B Seyger, Joost Schalkwijk |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
British Journal of Dermatology. 167:922-925 |
| ISSN: |
0007-0963 |
| DOI: |
10.1111/j.1365-2133.2012.10992.x |
| Popis: |
BACKGROUND: Recent genome-wide association studies have identified several genetic risk factors for psoriasis, but data on their association with age at onset are lacking. OBJECTIVES: To compare the association between known risk alleles and psoriasis in well-defined cohorts with paediatric- and adult-onset psoriasis. METHODS: Based on previous studies we selected seven genes and loci associated with psoriasis. Patients with paediatric-onset ( /= 18 years) and controls were genotyped. Genotype frequencies were compared between controls (n = 450) and all cases (n = 217), and between controls and cases stratified for confirmed age at onset (paediatric onset n = 80, adult onset n = 85). RESULTS: Paediatric-onset psoriasis showed a significant association with single nucleotide polymorphisms in the ERAP1 (P = 0.042) and IL23R loci (P = 0.042), LCE3C_LCE3B-del (P = 0.003) and HLA-C*06 (P = 1.72 x 10(-19)) when compared with the control group. A significant association of these four genes was also demonstrated when all psoriasis cases were compared with controls. In adult-onset psoriasis a significant association was found for HLA-C*06 (P = 5.11 x 10(-6)) and for LCE3C_LCE3B-del (P = 0.042). No associations were found for the IFIH1, IL12B and TRAF3IP2 loci. CONCLUSIONS: Notwithstanding the small cohort sizes, we demonstrated an association with established and recently discovered genetic risk factors in paediatric-onset psoriasis including genes involved in epidermal barrier function and adaptive immunity. Our data suggest that heritable factors may play a more important role in paediatric-onset psoriasis than in adult-onset psoriasis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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