Critical Roles of Non-coding RNAs in Acute Lymphoblastic Leukemia

Autor:	Maryam Mazloumi Gavgani, Saeid Ghorbian, Mansooreh Nargesian
Rok vydání:	2018
Předmět:	Regulation of gene expression Tumor suppressor gene microRNA RNA Computational biology Signal transduction Biology Non-coding RNA Genomic imprinting Chromatin remodeling
Zdroj:	Gene, Cell and Tissue.
ISSN:	2345-6833 2345-6841
DOI:	10.5812/gct.83297
Popis:	MicroRNA (miRNA) is one of the non-coding RNA (ncRNA) molecules with 21 - 25-nucleotide length, playing an important role in gene control by transcriptional gene regulation, chromatin remodeling, genetic imprinting, and translation initiation. The deregulation of ncRNA can lead to several hematopoietic malignancies such as acute lymphoblastic leukemia (ALL). The study aimed to draw the crucial features of miRNA in the pathogenesis of ALL. The findings showed that miRNA expression changes in ALL are typical and involve several signaling pathways. The variations in miRNA gene expression can lead to the incomplete expression of oncoprotein or tumor suppressor gene (TSG). It seems that ncRNAs play pivotal roles in the ALL pathogenesis. However, ncRNAs might be interested as potential diagnostic and prognostic biomarkers in ALL.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::221e45de7d06a0297b3d1f3b4e8e2620 https://doi.org/10.5812/gct.83297 Zobrazit plný text záznamu